Amiodarone
 
Presentation
• 150mg in 3ml ampoule
Pharmacology
• A Class III anti-arrhythmic agent
Actions
• Anti-arrhythmic
Metabolism
• By the liver
Primary Emergency Indications
• VF or Pulseless VT refractory to cardioversion Adult
• Sustained or recurrent VT Adult Paed
Contraindications

• Nil of significance in patients with VF or Pulseless VT refractory to cardioversion:
• Inadequate and rapidly deteriorating perfusion or Pregnancy in patients with VT
• Tricyclic antidepressant medication overdose

Precautions
• Following Fentanyl administration
Route of Administration
• IV
Side Effects
• Hypotension
• Bradycardia
Special Notes
• Amiodarone is incompatible with saline. Glucose 5% must be used as dilutant when administered to the conscious Pt.
• An intravenous infusion of Amiodarone may be required during interhospital transfer. This will be prescribed by the referring physician and will normally be at a rate of 15mg/kg/day minimun.
Therapeutic Effect
IV Bolus     
Onset:
2min
Peak:
20min
Duration:
120min
 
Reference Dilutions
Amiodarone Infusion (VT)
Amiodarone IV (Paed)