Aspirin |
Presentation |
• 300mg chewable tablets • 300mg soluble or water dispersible tablets |
|||||||||
Pharmacology |
• An analgesic, antipyretic, anti-infammatory and antiplatelet aggregation agent. | |||||||||
Actions |
• Reduces platelet aggregation • Inhibits synthesis of prostaglandins - anti-infammatory actions |
|||||||||
Metabolism |
• Converted to salicylate in the gut mucosa and liver, excreted mainly by the kidneys | |||||||||
Primary Emergency Indications |
• To minimise platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in acute coronary syndrome Adult | |||||||||
| • Hypersensitivity to aspirin/salicylates • Actively bleeding peptic ulcers • Bleeding disorders • Suspected dissecting aortic aneurysm • Chest pain associated with psychostimulant overdose if BP >160 |
||||||||||
Precautions |
• Peptic ulcer • Asthma • Pts on anti-coagulants, e.g. Warfarin |
|||||||||
Route of Administration |
• Oral | |||||||||
Side Effects |
• Heartburn, nausea, gastrointestinal bleeding • Hypersensitivity reactions • Increased bleeding time |
|||||||||
Special Notes |
• Aspirin is contraindicated for use in acute febrile illness in children and adolescents • The anti-platelet effects of Aspirin persist for the natural life of platelets |
|||||||||
Therapeutic Effect |
|
|||||||||
| Further Reding | Clinical Notes by Jeff Kenneally: Aspirin |