Metoclopramide |
Presentation |
• 10mg in 2ml ampoule | ||||||||||||||||||||||||
Pharmacology |
• Antiemetic | ||||||||||||||||||||||||
Actions |
• Accelerates gastric emptying and peristalsis • Mild SHT3-receptor antagonist |
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Metabolism |
• By the liver and excreted by the kidneys | ||||||||||||||||||||||||
Primary Emergency Indications |
• Nausea/vomiting Adult associated with: - Chest pain/discomfort of a cardiac nature - Opioid administration for pain - Previously diagnosed Migraine - Cytotoxic or radiotherapy - Severe gastroenteritis - Treatment or prophylaxis in awake spinal immobilised Pts - Eye trauma |
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| • Children • Suspected bowel obstruction or perforation • Gastrointestinal haemorrhage |
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Precautions |
• Undiagnosed abdominal pain • Adolescents (<20yrs) • Administer slowly over one minute to minimise risk of extrapyramidial reactions |
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Route of Administration |
• IV • IM |
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Side Effects |
• Drowsiness • Lethargy • Dry mouth • Muscle tremor • Extrapyramidial reactions (usually the dystonic type) |
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Special Notes |
• Not effective for established motion sickness • Not effective for nausea prophylaxis in the setting of narcotic administration |
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Therapeutic Effect |
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