Prochlorperazine
 
Presentation
• 12.5mg in 1ml amp
Pharmacology
• Antiemetic
Actions
• Acts on several central neuro-transmitter systems
Metabolism
• Metabolised by the liver and excreted by the kidneys
Primary Emergency Indications
• Treatment or prophylaxis of nausea/vomiting Adult for:
  - Motion sickness
  - Planned aeromedical evacuation
  - Known allergy or contraindication to Metoclopramide administration
  - Headache irrespective of nausea/vomiting
  - Vertigo
Contraindications
• Children
• Circulatory collapse
• CNS depression
• Previous hypersensitivity
Precautions
• Hypotension
• Epilepsy
• Pts effected by alcohol or on anti-depressants
Route of Administration
• IM
Side Effects
• Drowsiness
• Blurred vision
• Hypotension
• Sinus tachycardia
• Skin rash
• Extrapyramidal reactions, usually the dystonic type
Special Notes
 
Therapeutic Effect
IM     
Onset:
20min
Peak:
40min
Duration:
6hr