Misoprostol |
Presentation |
• 200mcg tablet | ||||||||||||
Pharmacology |
• A synthetic prostaglandin | ||||||||||||
Actions |
• Causes contractions of uterus | ||||||||||||
Metabolism |
• Converted to active metabolite Misoprostol Acid in the blood Metabolised in the tissues and excreted by the kidneys | ||||||||||||
Primary Emergency Indications |
• Primary Post Partum Haemorrhage Obst | ||||||||||||
| • Allergy to prostaglandins | |||||||||||||
Precautions |
• History of Asthma • Ensure multiple pregnancy excluded before drug administration |
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Route of Administration |
• Oral | ||||||||||||
Side Effects |
• Hyper-pyrexia • Shivering • Abdominal pain • Diarrhoea |
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Special Notes |
• Side effects more likely with >600mcg oral dose | ||||||||||||
Therapeutic Effect |
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